A brain DNA co-methylation network analysis of psychosis in Alzheimer's disease.

ABSTRACT:

Introduction

The presence of psychosis in Alzheimer's disease (AD) is suggested to be associated with distinct molecular and neuropathological profiles in the brain.

Methods

We assessed brain DNA methylation in AD donors with psychosis (AD+P) and without psychosis (AD-P) using the EPIC array. Weighted gene correlation network analysis identified modules of co-methylated genes in a discovery cohort (PITT-ADRC: N = 113 AD+P, N = 40 AD-P), with validation in an independent cohort (BDR: N = 79 AD+P, N = 117 AD-P), with Gene Ontology and cell-type enrichment analysis. Genetic data were integrated to identify methylation quantitative trait loci (mQTLs), which were co-localized with GWAS for related traits.

Results

We replicated one AD+P associated module, which was enriched

SUBMITTER: Kouhsar M 

PROVIDER: S-EPMC11815327 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature