Overexpression of SHANK2 contributes malignant outcomes as a Hippo pathway regulator in gastric cancer.

ABSTRACT:

Background

Recent studies identified that SH3 and multiple ankyrin repeat domains 2 (SHANK2) is located in a gene-amplified region 11q13 of various human cancers, and has oncogenic functions as a Hippo pathway suppressor in hepatocellular carcinoma. In this study, we tested whether SHANK2 acts as a cancer-promoting gene through its activation or overexpression in gastric cancer (GC).

Materials and methods

We analyzed 5 GC cell lines and 172 primary tumor samples of GC, which were curatively resected in our hospital.

Results

Overexpression of SHANK2 protein was frequently detected in GC cell lines (4/5 cell lines, 80%). Knockdown of SHANK2 inhibited cell proliferation, migration and invasion of GC cells in a TP53 mutation-independent manner, and induced the over

SUBMITTER: Arakawa H 

PROVIDER: S-EPMC11815361 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature