Hinokitiol reduces tumor metastasis by regulating epithelial cell adhesion molecule via protein kinase-B/mammalian target of rapamycin signaling pathway.

ABSTRACT: Tumor metastasis is the leading cause of death in cancer patients. Epithelial cell adhesion molecule (EpCAM) is abundantly expressed in various malignant tumors and plays a crucial role in cell adhesion, metastasis, proliferation, and differentiation. This study investigated the effects of hinokitiol, a natural tropolone compound known for its antiviral, anti-inflammatory, and antibacterial properties, on tumor growth and metastasis. Specifically, the study focused on the expression of EpCAM in mouse tumor cells treated with hinokitiol. Hinokitiol was administered to mouse melanoma cells (B16F10) and mouse colorectal carcinoma cells (CT26), resulting in a significant decrease in EpCAM expression. Additionally, the protein levels involved in the protein kinase-B/mammalian target of rapamyci

SUBMITTER: Wu PS 

PROVIDER: S-EPMC11815376 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature