Association between education and walking speed: counterfactual mediation analysis in favor of a motor reserve hypothesis.

ABSTRACT: We quantified the extent to which the association between education and fast walking speed (FWS) is explained by 17 mediators (cardiovascular risk factors/diseases, comorbidities, health behaviors, socioprofessional characteristics, cognition), and examined whether mediators interact with education, in favor of a reserve hypothesis. Cross-sectional analyses are based on Constances (a population-based study of French adults 45-69 years). Three-meter FWS was measured using photoelectric cells. Education was categorized as lower vs higher. After multiple imputation of missing values, we used counterfactual mediation models for multiple mediators allowing for education × mediator interactions, to estimate the total effect (TE), total indirect effect (TIE), and mediated interaction (IMD) of low

SUBMITTER: Santos F 

PROVIDER: S-EPMC11815503 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature