Lithium for Bipolar Disorder and Risk of Thyroid Dysfunction and Chronic Kidney Disease.

ABSTRACT:

Importance

Literature indicates adverse effects of lithium on thyroid and kidney function. However, existing data are heterogeneous, with limitations in quality and lack evaluation of adverse effects of lithium vs other mood stabilizers, especially commonly prescribed second-generation antipsychotics. Lithium serum level thresholds associated with thyroid and kidney abnormalities remain unknown.

Objective

To examine risk of thyroid and kidney dysfunction in patients with incident bipolar disorder (BD) treated with lithium and other mood stabilizers and antipsychotics in an Asian population and to determine lithium serum level cutoffs associated with these physical complications.

Design, setting, and participants

This population-based retrospective cohort study identif

SUBMITTER: Chan JKN 

PROVIDER: S-EPMC11815528 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature