Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected host.

ABSTRACT: In contrast to many other virus infections, primary cytomegalovirus (CMV) infection does not fully protect against reinfection. Accordingly, clinical data have revealed a coexistence of multiple human CMV variants/strains in individual patients. Notably, the phenomenon of multiple infection was found to correlate with increased virus load and severity of CMV disease. Although of obvious medical relevance, the mechanism underlying this correlation is unknown. A weak immune response in an individual could be responsible for a more severe disease and for multiple infections. Alternatively, synergistic contributions of variants that differ in their biological properties can lead to qualitative changes in viral fitness by direct interactions such as genetic recombination or functional complemen

SUBMITTER: Cicin-Sain L 

PROVIDER: S-EPMC1181553 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature