Temporal Interference Stimulation Boosts Working Memory Performance in the Frontoparietal Network.

ABSTRACT: Temporal interference (TI) stimulation is a novel neuromodulation technique that overcomes the depth limitations of traditional transcranial electrical stimulation while avoiding the invasiveness of deep brain stimulation. Our previous behavioral research has demonstrated the effects of multi-target TI stimulation in enhancing working memory (WM) performance, however, the neural mechanisms of this special form of envelope modulation remain unclear. To address this issue, here we designed this randomized, double-blind, crossover study, which consisted of a task-based functional magnetic resonance imaging (fMRI) experiment, to explore how offline TI stimulation modulated brain activity and behavioral performance in healthy adults. We conducted a 2 × 2 within-subjects design with two factors:

SUBMITTER: Zheng S 

PROVIDER: S-EPMC11815565 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature