Precise functionalization in nano-confinement: a bottom-up approach to the evolution of selective molecular receptors.

ABSTRACT: Precise molecular recognition depends on the delicate interplay between a guest molecule and a host possessing complementary functional groups. The de novo design of selective artificial receptors remains a formidable challenge, given the complexity of predicting these interactions. We present herein a bottom-up approach to the evolution of selective molecular receptors through precise endo-functionalization of a supramolecular cage. Internal functional groups were introduced within the heteroleptic palladium coordination cage in a site-precise fashion. With just five different functional groups, we successfully created a library of 32 isoreticular nano-cages, each featuring a unique micro-environment, by varying the nature, location and combination of endo-functional

SUBMITTER: Tan YM 

PROVIDER: S-EPMC11815571 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature