Model-based fed-batch cultivation of <i>Viola odorata</i> plant cells exhibiting antimalarial and anticancer activity.

ABSTRACT:

Introduction

Viola odorata is a medicinal plant used in the indigenous systems of medicine in India, to treat respiratory tract disorders. V. odorata natural plant source is limited in availability. Bioprocess principles can be applied to develop sustainable methods for the commercial production of high-quality V. odorata plant biomass.

Methods

To this effect, the in vitro culture conditions of V. odorata were rationally optimized to increase the biomass production up to 21.7 ± 0.8 g DW L^-1 in 12 days in shake flasks. In the current study, a modified stirred tank reactor and a balloon-type bubble column reactor were used to improve the biomass production at the batch reactor level. Sufficient nutrient feeding strategies were deve

SUBMITTER: Babu R 

PROVIDER: S-EPMC11815595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature