Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment.

ABSTRACT: Ex vivo machine perfusion or normothermic machine perfusion is a preservation method that has gained great importance in the transplantation field. Despite the immense opportunity for assessment due to the beating state of the heart, current clinical practice depends on limited metabolic trends for graft evaluation. Hemodynamic measurements obtained from left ventricular loading have garnered significant attention within the field due to their potential as objective assessment parameters. In effect, this protocol provides an easy and effective manner of incorporating loading capabilities to established Langendorff perfusion systems through the simple addition of an extra reservoir. Furthermore, it demonstrates the feasibility of employing passive left atrial pressurization for loading, an

SUBMITTER: Olverson G 

PROVIDER: S-EPMC11815639 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature