Multiomic Sequencing Reveals Distinctive Gene Expression and Epigenetic Alterations Associated With Primary Sclerosing Cholangitis Development in Treatment-Naive Pediatric Ulcerative Colitis.

ABSTRACT:

Background and aims

Primary sclerosing cholangitis (PSC) is a progressive cholestatic disease with up to 80% of patients also suffering from ulcerative colitis (PSC-UC). The difficulty in the diagnosis along with the increased risk for developing cancer represents a clinical challenge. Furthermore, the precise molecular factors regulating the phenotype of this disease subtype remain unknown.

Methods

We applied methyl-capture sequencing and mRNA sequencing to colonic mucosal biopsies from 3 groups of treatment-naïve children at diagnosis from the Determinants and Outcomes in CHildren and AdolescentS study: UC (n = 10), PSC-UC (n = 10), and healthy controls (n = 10).

Results

Differential gene expression between UC and PSC-UC showed significantly higher gene expression c

SUBMITTER: Rodriguez-Sosa A 

PROVIDER: S-EPMC11815658 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature