Caffeine ameliorates metabolic-associated steatohepatitis by rescuing hepatic Dusp9.

ABSTRACT: Caffeine (CAFF) is abundant in black coffee. As one of the most widely consumed beverages globally, coffee has been the focus of increasing clinical and basic research, particularly regarding its benefits in alleviating metabolic dysfunction-associated steatotic liver disease (MASLD). However, the therapeutic effects of CAFF on metabolic-associated steatohepatitis (MASH) and the underlying mechanisms remain unclear. In this study, we demonstrated that CAFF potently reduced hepatic steatosis, inflammation, and early-stage liver fibrosis in MASH mice induced by prolonged (36 weeks) high-fat high-carbohydrate (HFHC) diets and high-fat diets combined with carbon tetrachloride (CCl₄) injections. By using multiple target-identifying strategies, including surface plasmon resonance (SPR

SUBMITTER: Xin X 

PROVIDER: S-EPMC11815699 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature