Tea Polyphenol Protects the Immune Barrier and Inhibits TLR2/NF-κB/MLCK Signal Activation to Prevent Inflammatory Injury in the Intestines of Common Carp (Cyprinus carpio L.).

ABSTRACT: Tea polyphenol (TP) is a kind of natural macromolecular compound present in tea extract with rich biological potential. The purpose of this study was to explore the protective effect of TP on the intestinal immune barrier and the related mechanisms of TP alleviating intestinal injury. Models of common carp (Cyprinus carpio L.) and primary intestinal epithelial cells treated with TP and lipopolysaccharide (LPS) were established. The qPCR and ELISA results showed that TP increased the levels of lysozyme (LZ), alkaline phosphatase (ALP), complement component 3 (C3), complement component 4 (C4), immunoglobulin T (IgT), immunoglobulin D (IgD), and immunoglobulin M (IgM) to activate intestinal immune ability. Molecular docking indicated that TP had a strong interaction with TLR2. Meanwhil

SUBMITTER: Qian M 

PROVIDER: S-EPMC11815732 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature