Downregulation of Aging-Associated Gene SUCLG1 Marks the Aggressiveness of Liver Disease.

ABSTRACT:

Introduction

The most common liver disease is nonalcoholic fatty liver disease, characterized by an intrahepatic accumulation of lipids that most often accompanies obesity. Fatty liver can evolve, in the presence of oxidative stress and inflammation, into disabling and deadly liver diseases such as cirrhosis, hepatocellular carcinoma (HCC), and cholangiocarcinoma (CC). Old age seems to favor HCC and CC, in agreement with the inflammaging theory, according to which aging accrues inflammation. Cancer, in general, is an age-related disease, as incidence and mortality for most types of cancer increase with age. However, how molecular drivers in tumors differ or are mutated more frequently among patients of different ages remains scarcely investigated. A recent integrative analysis of t

SUBMITTER: Tsoneva DK 

PROVIDER: S-EPMC11815819 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature