Prognostic Stratification of Epithelioid Pleural Mesothelioma Based on the Hippo-TEADs Network.

ABSTRACT: Background. The Hippo pathway is the most frequently altered signaling in pleural mesothelioma (PM). Epithelioid PM (ePM) is associated with better outcome than non-epithelioid subtypes, but its prognosis can be heterogeneous. Here, we tried to stratify ePM using the expression levels of the Hippo-TEAD network. Methods. Thirty patients with ePM were included in this study. Tumors were stratified using the expression levels of 74 genes belonging to the Hippo-TEAD network and using the non-negative matrix factorization algorithm. Results were validated using ePM cases from the TCGA cohort. Alterations associated with the molecular subgroups were investigated using mutation and copy number alteration data from TCGA. Results. Two groups of ePM (i.e., HP1 and HP2) were iden

SUBMITTER: Poma AM 

PROVIDER: S-EPMC11815884 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature