Association of Inflammatory Profile During <i>Ex Vivo</i> Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis.

ABSTRACT: PGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the association between the levels of proinflammatory biomarkers during EVLP and PGD3 development within the firsts 72 h post-Ltx. Biomarkers were categorized by timing (1-hour, T0 and 4-hours, Tend from EVLPstart) and by their biological function (adhesion molecules, chemokines, cytokines, damage-associated-molecular-patterns, growth-factors, metabolites). We employed a four-level mixed-effects model with categorical predictors for biomarker groups to identify differences between patients with PGD3

SUBMITTER: Costamagna A 

PROVIDER: S-EPMC11815944 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature