Developmental ethanol exposure produces deficits in long-term potentiation in vivo that persist following postnatal choline supplementation.

ABSTRACT:

Background

Fetal alcohol spectrum disorder (FASD) is one of the leading causes of neurodevelopmental disorder for which there is a pressing need for an effective treatment. Recent studies have investigated the essential nutrient choline as a postnatal treatment option. Supplementation with choline has produced improvements in behavioral tasks related to learning and memory and reverted changes in methylation signature following third-trimester equivalent ethanol exposure. We examined whether there are related improvements in hippocampal synaptic plasticity in vivo.

Methods

Sprague-Dawley offspring were administered binge-levels of ethanol from postnatal day (PND) 4 to 9, then treated with choline chloride (100 mg/kg/day) from PND 10 to 30. In vivo electrophysiology was perfo

SUBMITTER: Titterness AK 

PROVIDER: S-EPMC11816008 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature