Impact of guideline directed medical therapy on myocardial function in adults with congenital heart disease.

ABSTRACT:

Background

Guideline-directed heart failure therapy with angiotensin receptor blocker/neprilysin inhibitor (ARNi) and sodium-glucose transporter inhibitors (SGLT2i) has been incrementally beneficial in improving outcomes in heart failure patients.

Objective

Evaluate the feasibility and efficacy of guideline-directed medical therapy (GDMT) in adults congenital heart disease (ACHD) patients.

Methods

In a retrospective cohort study, ACHD patients with either New York Heart Association (NYHA) Class II symptoms or systemic ejection fraction (EF) <45%, optimized on a combination of beta-blocker (BB), ARNi, mineralocorticoid receptor antagonist (MRA) and SGLT2i were evaluated.

Results

Forty-six patients with a mean age 42.6 ± 12.1 years prescribed GDMT were identified

SUBMITTER: Bright C 

PROVIDER: S-EPMC11816014 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature