Association of iron status indicators with thyroid hormone concentrations during pregnancy: a systematic review and meta-analysis.

ABSTRACT:

Background

Maternal thyroid hormones play a vital role in fetal development, and imbalances can lead to adverse outcomes. Iron deficiency may impair thyroid function due to iron's essential role in iodine oxidation during thyroid hormone synthesis. This review examines the relationship between various indicators of maternal iron status and thyroid function during pregnancy.

Methods

We conducted a systematic search in MEDLINE/PubMed, Web of Science, Embase, Scopus, and the Cochrane Library for studies published up to 2023. Meta-analyses determined pooled thyroid hormone levels in patients with and without iron deficiency, using serum ferritin (cut-off = 30 µg/L) and hemoglobin (cut-off = 11 g/dL). Meta-regression analyses examined linear relationships between iron status indi

SUBMITTER: Parsaei M 

PROVIDER: S-EPMC11816114 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature