Effects of Interleukin-6 (IL-6) on In Vitro Cultured Equine Chorionic Girdle Cells.

ABSTRACT:

Introduction

Equine chorionic girdle cells can give rise to the endometrial cup, a structure that secretes equine chorionic gonadotropin (eCG). To date, the mechanisms underlying the proliferation, differentiation, invasion, and hormone secretion of equine chorionic girdle cells are not fully understood. During human pregnancy, interleukin-6 (IL-6) is maternally expressed to stimulate the invasion and migration of human syncytiotrophoblast cells and influence the synthesis of human chorionic gonadotropin. Although many previous studies reported the same upregulation of IL-6 during equine placentation, its effects on equine chorionic girdle cells have never been tested.

Methods

In this study, we tested the effects of different concentrations of IL-6 on the morphology, differe

SUBMITTER: Mu S 

PROVIDER: S-EPMC11816123 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature