Peptidergic Modulation of the Lobster Cardiac System Has Opposing Action on Neurons and Muscles.

ABSTRACT: Modulation of neuronal networks, primarily through neuropeptides, generates variations in motor patterns that allow organisms to adapt to environmental changes or sensory inputs. Modulation is complex, with receptors for neuromodulators expressed at various locations within a nervous system; neuromodulators can thus alter muscle dynamics peripherally via the neuromuscular junction (NMJ) and the muscle itself. The neurogenic cardiac neuromuscular system of the American lobster (Homarus americanus) is a well-characterized model for investigating peptidergic modulation. Myosuppressin (pQDLDHVFLRFamide) is an endogenous peptide that interestingly decreases contraction frequency while also increasing contraction force by acting at both the lobster heart central pattern generator (CPG; th

SUBMITTER: Petropoulos IS 

PROVIDER: S-EPMC11816307 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature