From water to land-Usage of Generalized Unified Threshold models of Survival (GUTS) in an above-ground terrestrial context exemplified by honeybee survival data.

ABSTRACT: In regulatory aquatic risk assessment, toxicokinetic-toxicodynamic (TKTD) methods, such as the generalized unified threshold model of survival (GUTS), are already established and considered ready for use, whereas TKTD methods for aboveground terrestrial species, like arthropods, are less developed and currently not intended for risk assessment. This could be due to the fact that exposure in aboveground terrestrial systems is more event-based (feeding, contact, overspray, etc.), whereas exposure in aquatic systems is simply related to substance concentrations in the surrounding water. To provide a generic TKTD framework for terrestrial invertebrates, we propose a new GUTS variant that includes an intermediate buffer between the external exposure and inside of the organism. This buffer can b

SUBMITTER: Burger LU 

PROVIDER: S-EPMC11816312 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature