Associations of paternal age with offspring under-five mortality and perinatal outcomes: a cohort study using claims data in Taiwan.

ABSTRACT:

Background

The causal relationship between advanced paternal age and offspring health is unclear, owing to familial confounders. This study examined the association of paternal age with offspring's under-five mortality and perinatal outcomes, using sibling comparison analyses to account for familial confounding factors.

Methods

A nationwide birth cohort study was designed based on Taiwan's single-payer compulsory National Health Insurance programme. Individuals born between 2001 and 2015 were included, resulting in 2454 104 live-born singletons. Among them, 1513 222 individuals had full sibling(s) who were included in the sibling-comparison analyses. Logistic regression analyses were used to evaluate the main study cohort whereas conditional logistic regressions were used in

SUBMITTER: Wang SH 

PROVIDER: S-EPMC11816320 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature