Transcriptome-Based Survival Analysis Identifies <i>MAP4K4</i> as a Prognostic Marker in Gastric Cancer with Microsatellite Instability.

ABSTRACT: Background/Objectives: Gastric cancer (GC) is a highly aggressive malignancy with diverse molecular subtypes. While microsatellite instability (MSI) GC generally carries a favorable prognosis, a subset of patients experiences poor outcomes, highlighting the need for refined prognostic markers. Methods: This study utilized transcriptomic and clinical data from two independent cohorts, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG), to identify novel prognostic genes in MSI-GC. Results: Through rigorous survival analysis, we identified high MAP4K4 expression (MAP4K4^high) as an independent and robust predictor of poor overall survival (OS) and disease-free survival (DFS) specifically within the MSI-GC subtype. MAP4K4^hig

SUBMITTER: Huamani Ortiz AJ 

PROVIDER: S-EPMC11816344 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature