The Gender-Biased Differential Effect of <i>KDM6A</i> Mutation on Immune Therapy in Urothelial Carcinoma: A Public Database Study.

ABSTRACT: Background/Objectives: It is said that genes that escape from X chromosome inactivation (XCI) contribute to gender differences. We analyzed the prognostic role of these genes and identified a gender-biased difference in prognosis according to KDM6A mutation in the immune therapy cohort (IMvigor 210). We also investigate the gender-biased differential effect of KDM6A mutation in several public databases of urothelial carcinoma (UC). Methods: We used AACR GENIE, The Cancer Genome Atlas, International Cancer Genome Consortium, several public databases related to immune therapy, chemotherapy, and BCG treatment. We studied the gender-biased prognostic role of KDM6A mutation in several cohorts and the association between KDM6A mutation and immune-related

SUBMITTER: Sekino Y 

PROVIDER: S-EPMC11816370 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature