An evaluation of in utero polycyclic aromatic hydrocarbon exposure on the neonatal meconium microbiome.

ABSTRACT:

Introduction

In utero exposure to environmental polycyclic aromatic hydrocarbon (PAH) is associated with neurodevelopmental impairments[1-8], prematurity[9-12] and low birthweight[9,13-15]. The gut microbiome serves as an intermediary between self and external environment; therefore, exploring the impact of PAH on microbiota may elucidate their role in disease. Here, we evaluated the effect of in utero PAH exposure on meconium microbiome.

Methods

We evaluated 49 mother-child dyads within Fair Start Birth Cohort with full term delivery and adequate meconium sampling. Prenatal PAH was measured using personal active samplers worn for 48 h during third trimester. Post-processing, 35 samples with adequate biomass were evaluated for association between tertile of PAH exposure (hig

SUBMITTER: Keerthy D 

PROVIDER: S-EPMC11816390 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature