Graphene Quantum Dots in Bacterial Cellulose Hydrogels for Visible Light-Activated Antibiofilm and Angiogenesis in Infection Management.

ABSTRACT: A novel bacterial cellulose (BC)-based composite hydrogel with graphene quantum dots (BC-GQDs) was developed for photodynamic therapy using blue and green light (BC-GQD_blue and BC-GQD_green) to target pathogenic bacterial biofilms. This approach aims to address complications in treating nosocomial infections and combating multi-drug-resistant organisms. Short-term illumination (30 min) of both BC-GQD samples led to singlet oxygen production and a reduction in pathogenic biofilms. Significant antibiofilm activity (>50% reduction) was achieved against Staphylococcus aureus and Escherichia coli with BC-GQD_green, and against Pseudomonas aeruginosa with BC-GQD_blue. Atomic force microscopy images revealed a substantial decrease in biofilm mass, accompanied by changes in s

SUBMITTER: Zmejkoski DZ 

PROVIDER: S-EPMC11816408 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature