Identifying climatic drivers of respiratory syncytial virus (RSV) seasonality in Antananarivo, Madagascar, 2011-2021: a sentinel surveillance study.

ABSTRACT:

Introduction

Respiratory syncytial virus (RSV) is a primary source of acute lower respiratory tract infection, the leading cause of death in children under 5. Over 99% of RSV-attributed deaths occur in low-income countries, including Madagascar. RSV transmission is linked to climate, driving highly seasonal dynamics.

Methods

We used generalised additive models (GAMs) to identify correlates of reported RSV infections in Antananarivo, Madagascar, from January 2011 to December 2021, then fit catalytic models to cumulative age-structured incidence to estimate age-specific force of infection (FOI). We fit a time-series susceptible-infected-recovered (TSIR) model to the dataset to estimate weekly RSV transmission, then evaluated associations with precipitation, humidity and temper

SUBMITTER: Randriambolamanantsoa TH 

PROVIDER: S-EPMC11816425 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature