Activity of Azole and Non-Azole Substances Against <i>Aspergillus fumigatus</i> in Clinical and Environmental Samples to Address Antimicrobial Resistance.

ABSTRACT: Aspergillus fumigatus is a common fungus which has gained attention due to its resistance to azole compounds, substances used in both medical and agricultural settings. One of the genetic alterations responsible for this resistance is the mutation TR₃₄/L98H in the cyp51A gene. The aim of this study was to understand the impact of azoles and non-azoles on Aspergillus fumigatus. By examining clinical samples, soil samples, and compost material, this research aims to provide insights into the susceptibility of these strains to antifungal substances. To deepen our understanding of the factors potentially involved in antifungal resistance, we combined in vitro studies of sixteen compounds against Aspergillus fumigatus with results from the sequencing of th

SUBMITTER: Sanseverino I 

PROVIDER: S-EPMC11816432 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature