Causal roles of immune cells and metabolites in chronic pancreatitis: a mendelian randomization study.

ABSTRACT:

Background

Previous research has established a correlation between immune cells and an increased likelihood of Chronic pancreatitis (CP). However, studies investigating the causal relationship remain limited.

Methods

This study utilized publicly available genome-wide association study (GWAS) databases and conducted a two-sample Mendelian randomization (MR) analysis to examine the causal relationships (CRs) among 731 immune cells, 1,400 metabolites, and CP. Mediation MR analysis was also performed to assess whether metabolites serve as mediators in the relationship between immune cells and CP.

Results

Our study identified four immune cell types that act as risk factors for CP, with odds ratios (OR) ranging between 1.076 and 1.177. In contrast, three immune cell types w

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11816568 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature