The Role of Maladaptive Plasticity in Modulating Pain Pressure Threshold Post-Spinal Cord Injury.

ABSTRACT:

Background

Spinal cord injury (SCI) frequently leads to pain, leading to significant disability. Pain sensitization, a key feature of SCI, is commonly assessed via quantitative sensory testing like the Pressure Pain Threshold (PPT), though the factors influencing PPT changes remain unclear. This study hypothesizes that specific clinical and neurophysiological factors modulate PPT in SCI patients. The primary objective is to identify predictors of PPT in SCI patients.

Methods

We conducted a cross-sectional analysis of neurophysiological, clinical, and demographic data from 102 SCI patients in an ongoing prospective cohort study called "Deficit of Inhibition as a Marker of Neuroplasticity" (DEFINE study). Multivariable regression analyses were used to evaluate demographic, cli

SUBMITTER: Imamura M 

PROVIDER: S-EPMC11816816 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature