Characterization of spreading depolarizations in swine following superior sagittal sinus occlusion: a novel gyrencephalic model study.

ABSTRACT: Cerebral sinus thrombosis, which constitutes a small percentage of all strokes, usually affects young individuals and can lead to venous stroke. Ischemic and hemorrhagic Stroke are associated with Spreading Depolarization (SD) waves in brain tissue, which propagate through the affected areas and cause a transient disruption of ionic homeostasis and neuronal function. This interaction highlights the complexity of the neurological consequences associated with SD. In this study, we investigated the occurrence of SDs following the occlusion of the superior sagittal sinus (SSS) in a gyrencephalic model, specifically swine. To instigate an occlusion, we surgically clipped the middle third of the SSS. The animals were grouped and monitored using one of three methods: electrocorticography (ECoG) a

SUBMITTER: Sanchez-Porras R 

PROVIDER: S-EPMC11816831 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature