Effect of Neutron Radiation on ¹⁰BPA-Loaded Melanoma Spheroids and Melanocytes.

ABSTRACT: Melanoma is an aggressive disease that arises from mutations in the cells that produce the pigment melanin, melanocytes. Melanoma is characterized by a high mortality rate, due to avoidance of applied therapies and metastasis to other organs. The peculiar features of boron neutron capture therapy (BNCT), particularly its cell-level selectivity, make BNCT a promising modality for melanoma treatment. However, appropriate cellular models should be used to study new therapies or improve the efficacy of existing therapies. Spheroids, which have been used for years for in vitro studies of the efficacy of anti-cancer therapies, have many characteristics shared with tumors through which they can increase the accuracy of the cellular response compared to 2D culture in vitro studies and reduce the u

SUBMITTER: Szczepanek M 

PROVIDER: S-EPMC11816858 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature