New Terpenoids and Lignans from <i>Phyllanthus acidus</i> Fruits with Antioxidant Activity.

ABSTRACT: The fruits of Phyllanthus acidus, rich in various secondary metabolites and possessing significant antioxidant activity, have been consumed widely by many Southeast Asian people, including the Thai, Vietnamese, Burmese, Laotians, and Cambodians. An extensive investigation of the secondary metabolites of the fruits resulted in our obtaining 17 compounds, including four new compounds (1-4). The absolute configurations of 1, 3, and 4 were determined by comparing their experimental electronic circular dichroism (ECD) spectra with both reference data and computed ECD profiles. At a concentration of 40μM, terpenoids (1 and 5-9) showed no cytotoxic activity against five strains of human tumor cells and one of normal cells. Notably, th

SUBMITTER: Xin Y 

PROVIDER: S-EPMC11816990 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature