Antimicrobial Blue Light Reduces Human-Wound Pathogens' Resistance to Tetracycline-Class Antibiotics in Biofilms.

ABSTRACT: Biofilms contribute to chronic infections and the development of antimicrobial resistance (AMR). We are developing an antimicrobial blue light (aBL) device to reduce bacterial bioburden in wounds and decrease reliance on systemic antibiotics. aBL induces the generation of reactive oxygen species (ROS) through photoexcitation of endogenous chromophores, causing bacterial damage and death. This study explores the combination of tetracyclines (TCs) with aBL for the treatment of biofilm infections in vitro. Tetracyclines (TCs), including second-generation minocycline (MC), doxycycline (DOCT), and third-generation agents omadacycline (OM) and tigecycline (TG), were evaluated for their ability to enhance bactericidal effects and ROS production during aBL treatment of abiotic biofilm. TCs were te

SUBMITTER: Negri LB 

PROVIDER: S-EPMC11817061 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature