Anthocyanins in Black Soybean Coats Promote Apoptosis in Hepatocellular Carcinoma Cells by Regulating the JAK2/STAT3 Pathway.

ABSTRACT: The use of black soybean (Glycine max L.), an edible crop prevalent in Asia, has attracted attention for its hepatoprotective properties. Notably, the anthocyanin components in black soybean coats have shown potential in inhibiting tumor growth. Here, anthocyanins were extracted from black soybean coats using both microwave and water bath methods. The physicochemical characteristics of black soybean coat anthocyanins (BSCAs) and their biological activities were examined. The results from the MTT and EDU assays demonstrated a dose-dependent inhibitory effect of BSCAs on hepatocellular carcinoma HepG2 cells, while leaving normal cells unaffected. Flow cytometry and mitochondrial membrane potential assays revealed that BSCA treatment induces apoptosis in HepG2 cells. A network pharmaco

SUBMITTER: Li Y 

PROVIDER: S-EPMC11817063 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature