P27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer.

ABSTRACT: p27^Kip1 is a key cell cycle gatekeeper governing the timing of Cyclin-dependent kinase (CDK) activation/inactivation and, consequently, cell proliferation. Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhances the number of regulated cellular processes. p27^Kip1, like other intrinsically unstructured proteins, is post-translationally modified on several residues. These modifications affect its cellular localization and address p27^Kip1 for specific interactions/functions. Several germline or somatic CDKN1B (the p27^Kip1 encoding gene) mutations have been demonstrated to be associated with multiple endocrine neoplasia type 4 (MEN4), hairy cell leukemia, small-intestine neur

SUBMITTER: Bencivenga D 

PROVIDER: S-EPMC11817124 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature