PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis.

ABSTRACT:

Background

Beta-diversity is a fundamental ecological metric for exploring dissimilarities between microbial communities. On the functional dimension, metaproteomics data can be used to quantify beta-diversity to understand how microbial community functional profiles vary under different environmental conditions. Conventional approaches to metaproteomic functional beta-diversity often treat protein functions as independent features, ignoring the evolutionary relationships among microbial taxa from which different proteins originate. A more informative functional distance metric that incorporates evolutionary relatedness is needed to better understand microbiome functional dissimilarities.

Results

Here, we introduce PhyloFunc, a novel functional beta-diversity metric that inc

SUBMITTER: Wang L 

PROVIDER: S-EPMC11817178 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature