Evolutionary Patterns and Genotype-Specific Amino Acid Mutations of Tick-Borne Encephalitis Virus.

ABSTRACT: Tick-borne encephalitis virus (TBEV) is a significant tick-borne flavivirus responsible for severe human diseases. Here, we analyzed the genetic diversity and evolutionary dynamics of TBEV using 263 genome sequences from the NCBI database and identified key amino acid mutations. TBEV sequences were classified into five genotypes-Baikalian, European, Far-Eastern, Himalaya, and Siberian-showing ORF nucleotide similarity of 81.5% to 88.0% and amino acid similarity of 93.0% to 96.4%. Extensive recombination between genotypes was not observed. Entropy analyses revealed highly variable sites distributed across the Baikalian (n = 2), European (n = 3), Far-Eastern (n = 5), and Siberian (n = 13) genotypes. Each genotype exhibited specific amino acid mutations. Positive selection analysis identified

SUBMITTER: Wang R 

PROVIDER: S-EPMC11817229 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature