White matter alterations in episodic migraine without aura patients assessed with diffusion MRI: effect of free water correction.

ABSTRACT:

Objective

To assess the effect of modeling free water (FW) on the identification of white matter (WM) microstructure alterations using diffusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls.

Background

Diffusion tensor imaging (DTI) studies examining WM in migraine patients previously overlooked the potential influence of FW partial volume effects. Correcting FW effects could offer a clearer understanding of WM changes in migraine. This study is the first to incorporate FW effects when evaluating alterations in WM tracts in migraine patients, offering a comparison to standard DTI analysis.

Methods

A group of 14 patients with low-frequency episodic menstrual-related migraine without aura and 15 healthy cont

SUBMITTER: Guadilla I 

PROVIDER: S-EPMC11817245 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature