Preparation of Diosgenin-Functionalized Gold Nanoparticles: From Synthesis to Antitumor Activities.

ABSTRACT: Cancer ranks among the top causes of illness and death globally. Nanotechnology holds considerable promise for enhancing the effectiveness of therapeutic and diagnostic approaches in cancer treatment. Our study presents a promising strategy for applying thiocompound nanomedicine in cancer therapy. Our first study aimed to investigate the biological properties of a new compound thiodiosgenin (TDG)-a new derivative of diosgenin-a natural compound with known antioxidant and anticancer properties. Our current second study aimed to compare the therapeutic efficacy of a new diosgenin-functionalized gold nanoparticles-with its precursor on prostate cancer (DU-145) cell lines. Moreover, the safety of the new thio-derivative and new conjugates was tested against the human epithelial line PNT-2. New

SUBMITTER: Stolarczyk EU 

PROVIDER: S-EPMC11817374 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature