Intra-Tumoral CD8+:CD3+ Lymphocyte Density Ratio in Appendix Cancer Is a Tumor Volume- and Grade-Independent Predictor of Survival.

ABSTRACT:

Background

The immune contexture of solid tumors plays a critical role in cancer progression and response to immunotherapy. However, immunologic characterization of appendiceal cancer (AC) has lagged behind advancements in other gastrointestinal malignancies. This study aims to define the AC immune microenvironment by quantifying CD3+ and CD8+ lymphocyte densities and assessing their prognostic significance.

Methods

Archival tissue samples from 95 AC patients were analyzed using immunohistochemistry to assess CD3+ and CD8+ T cell densities and their ratios. Associations between lymphocyte density and clinical, pathologic, and oncologic variables were examined using Spearman's correlation, Kruskal-Wallis tests, and Cox proportional hazards analysis.

Results

Tumor sampl

SUBMITTER: Knotts C 

PROVIDER: S-EPMC11817446 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature