Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology.

ABSTRACT: Introduction: Meningiomas are the most common primary central nervous system tumors, constituting 39.7% of intracranial tumors. Although generally benign, some exhibit aggressive behavior and risk of recurrence, necessitating adjuvant therapy and repeat surgical interventions. Molecular studies have identified tumor-driving mutations, leading to targeted therapies and clinical trials. However, translating preclinical findings into clinical success is often hindered by limitations in current meningioma tumor models. This study aims to develop and validate a standardized protocol for establishing patient-derived meningioma organoids (MEN-Os) that faithfully replicate human disease. Methods: MEN-Os were successfully established from 15 meningioma samples (11 grade

SUBMITTER: Zohdy YM 

PROVIDER: S-EPMC11817449 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature