Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats.

ABSTRACT:

Background

Type 1 diabetes mellitus is associated with accelerated skeletal muscle aging and sarcopenia, a condition characterized by muscle mass and function loss. Early and noninvasive evaluation of muscle microstructural damage is critical for managing sarcopenia in diabetes. This study evaluated the potential of MRI texture analysis as a noninvasive imaging tool to assess myofiber size and grip strength alterations in a rat model of diabetic sarcopenia.

Materials and methods

Twenty SD rats were randomly and evenly allocated to the control (CON) and diabetic sarcopenia (DS) groups. Blood glucose, body weight, and forelimb grip strength were measured weekly. In the eighth week, axial T₁WI and T₂WI scans were performed to extract 16 texture features of

SUBMITTER: Xing D 

PROVIDER: S-EPMC11817564 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature