Delivering miR-23b-3p by small extracellular vesicles to promote cell senescence and aberrant lipid metabolism.

ABSTRACT:

Background

Aging is a natural process that affects the majority of organs within the organism. The liver, however, plays a pivotal role in maintaining the organism's homeostasis due to its robust regenerative and metabolic capabilities. Nevertheless, the liver also undergoes the effects of aging, which can result in a range of metabolic disorders. The function of extracellular vesicles and the signals they convey represent a significant area of interest within the field of ageing research. However, research on liver ageing from the perspective of EVs remains relatively limited.

Results

In the present study, we extracted liver tissue small extracellular vesicles (sEVs) of mice at different ages and performed transcriptome and proteome analyses to investigate the senescence-as

SUBMITTER: Jin Y 

PROVIDER: S-EPMC11817603 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature