Short-Term Fasting Induces Hepatocytes' Stress Response and Increases Their Resilience.

ABSTRACT: Fasting leads to a range of metabolic adaptations that have developed through evolution, as humans and other mammals have unequal access to food over the circadian cycle and are therefore adapted to fasting and feeding cycles. We have investigated the role of a single fasting episode in rats in triggering the stress response of liver hepatocytes. Since the stress responses were observed in both animals and isolated cells, we investigated whether the effects of the animal stressor could persist in the cells after isolation. By measuring staurosporine-induced apoptosis, stress signalling, and oxidative and antioxidant responses in hepatocytes from fasted and ad libitum-fed animals, we found that only fasting animals elicited a stress response that prevented caspase-9 activation and persisted

SUBMITTER: Prsa P 

PROVIDER: S-EPMC11817670 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature