Challenges and preventive strategies in pediatric drug hypersensitivity reactions: where do we stand?

ABSTRACT: Drug hypersensitivity reactions (DHRs) in pediatric patients present significant clinical challenges due to their potential for severe, life-threatening reactions such as anaphylaxis. Although less common than in adults, DHRs in children are more difficult to diagnose and manage due to limited pediatric-specific research. This study focuses on the role of premedication as a preventive strategy for DHRs, exploring its potential benefits and limitations. While approaches like H1-antihistamines combined with gradual drug dose escalation show promise for reducing mild histamine-mediated reactions, evidence regarding premedication's effectiveness, particularly for non-IgE-mediated mechanisms, remains inconclusive. Rapid drug desensitization (RDD) protocols demonstrate high success rates in cert

SUBMITTER: Klain A 

PROVIDER: S-EPMC11817705 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature