Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity.

ABSTRACT:

Objective

The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.

Methods

In a prospective birth cohort of Dominican and African American children from New York City, New York (1998-2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed-effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age² were used to assess associations between age and adiposity trajectories.

Results

BMI was

SUBMITTER: Reddam A 

PROVIDER: S-EPMC11817725 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature