Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a key risk factor for cardiovascular disease (CVD), potentially driven by shared metabolic mechanisms. Metabolic perturbations associated with MASLD and CVD remain underexplored in people with HIV (PWH).

Methods

We used data from the longitudinal multicenter 2000HIV study comprising 1895 virally suppressed PWH, out of which 970 had available liver and carotid artery measurements. Transient elastography with controlled attenuation parameter (CAP) was performed for the assessment of liver steatosis (CAP > 263 dB/m) and fibrosis (LSM ≥ 7.0). Historic and future incident CVD within 2-year follow-up, defined as myocardial infarction, stroke, peripheral arterial disease, and angina pectoris, were extrac

SUBMITTER: van Eekeren LE 

PROVIDER: S-EPMC11817758 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature