Naringenin-loaded nanoparticles modulate HIF-driven oxygen-sensing pathways in lung adenocarcinoma cells.

ABSTRACT:

Background

Hypoxia is a common symptom of lung cancer. Proliferation and neovascularization mediated by hypoxia-inducible factors (HIF) influence several adaptations. It has recently been established that naringenin (NAR) and its nanoparticles are chemo-preventive flavonoids in lung cancer.

Aim

Adjust HIF activity by reviving oxygen-sensing enzyme activity while considering possible therapeutic targets.

Method

The bindings of NAR to target proteins were examined using computational modeling techniques. Additionally, NAR nanoparticles (NARNPs) were synthesized and characterized. Normal fibroblast cells and A549 cells were used to determine cytotoxicity. Colorimetric analysis of α-ketoglutarate detection for hydroxylases.

Results

According to molecular modeling,

SUBMITTER: Ragab EM 

PROVIDER: S-EPMC11817823 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature